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CHICAGO (AP) — Cipro, the antibiotic that became a household word during the 2001 anthrax scare, is becoming increasingly ineffective against other dangerous germs because of overuse, a study found.

The researchers examined data on infections in hospitalized patients in 43 states and Washington, D.C., from 1994 to 2000. Ailments included respiratory and urinary infections caused by a variety of bacteria.

Many germs had grown resistant to fluoroquinolones, a class of antibiotics that includes ciprofloxacin, known by the brand name Cipro.

In 1994, Cipro was effective against 86 percent of the bacteria samples analyzed, but that dropped to 76 percent by 2000, the researchers found.

Teva Pharmaceuticals is the latest generic drug company to receive tentative FDA approval to market the antibiotic cirpofioxacin, the unbranded form of Bayer’s Cipro. It goes off brand in December 2003. Mylan and Danbury Pharmacueuticals also plan generic launches.

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