lipitor and night sweats
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Preliminary results from a phrase III clinical trial have shown that Pfizer’s combined use of torcetrapid with to increase good cholesterol also increases blood pressure. Patients at risk from heart disease had their systolic blood pressure increased by two mm/Hg when taking and torcetrapid …
M2 PRESSWIRE-10 August 2006-U.S. Equity News: Pfizer’s Shown to Reduce the Chance of Additional Strokes in Stroke Patients and Millennium Cancer Drug Gets FDA Priority(C)1994-2006 M2 COMMUNICATIONS LTD RDATE:10082006 City of Industry, CA - Pharmaceuticals Instruments industry alert provided by U.S.
Main article: Statin
As with other statins, atorvastatin is a competitive inhibitor of HMG-CoA reductase. Unlike most others, however, it is a completely synthetic compound. HMG-CoA reductase catalyzes the reduction of 3-hydroxy-3-methylglutaryl-coenzyme A (HMG-CoA) to mevalonate, which is the rate-limiting step in hepatic cholesterol biosynthesis. Inhibition of the enzyme decreases de novo cholesterol synthesis, increasing expression of low-density lipoprotein receptors (LDL receptors) on hepatocytes. This increases LDL uptake by the hepatocytes, decreasing the amount of LDL-cholesterol in the blood. Like other statins, atorvastatin also reduces blood levels of triglycerides and slightly increases levels of HDL-cholesterol.
In clinical trials, adding ezetimibe (Zetia) to lowered cholesterol more effectively than Vytorin (ezetimibe + simvastatin).[citation needed].