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* The estimated $18 million dollar direct-to-consumer advertising account for has been placed with Cline, Davis & Mann. Ads for Pfizer’s liquid dose form of the antibiotic for children will promote treatment of ear infections among other bacterial infections. Pfizer is promoting to patients and physicians in face of a recommendation by the Centers for Disease Control (CDC) and Prevention that amoxicillin should be the drug of choice and along with other antibiotics lack good evidence of effectiveness.
Most common side effects are gastrointestinal; diarrhea (4-5%), nausea (3%), abdominal pain (2-3%) and vomiting. Fewer than 1% of patients stop taking the drug due to side effects. Serious allergic reactions, nervousness, dermatologic reactions, and fatalities have been reported but are extremely rare. Increased appetite may or may not occur in the patient. As with all antimicrobial agents, pseudomembranous colitis can occur during and up to several weeks after azithromycin therapy. This drug may interfere with the effectiveness of birth control pills; other forms of contraception may be required during the treatment period. Although mild diarrhea is normal, if it is moderate to severe, or if it continues or is bothersome, check with your doctor. If you experience vomiting, or hearing loss or ringing in the ears, contact your doctor as soon as possible.